Department of Chemistry and Biochemistry, University of Hull, Hull, HU67RX, UK. We have developed and tested copper oxide nanoparticles (CuONPs) grafted with (3-glycidyloxypropyl)trimethoxysilane (GLYMO) and coupled with 4-hydroxyphenylboronic acid (4-HPBA), which provides a very robust boost of their motion as anti-algal and anti-yeast agents. The boronic acid terminal teams on the surface of the CuONPs/GLYMO/4-HPBA can form reversible covalent bonds with the diol teams of glycoproteins and carbohydrates expressed on the cell surface the place they bind and accumulate, which isn’t primarily based on electrostatic adhesion. Results showed that, the impression of the 4-HPBA grafted CuONPs on microalgae (C. CuONPs and CuONPs/GLYMO at the identical particle focus. SEM and TEM imaging revealed that 4-HPBA-functionalized CuONPs nanoparticles can accumulate more on the cell walls than non-functionalized CuONPs. We found a marked increase of the 4-HPBA functionalized CuONPs action on these microorganisms at shorter incubation times in contrast with the bare CuONPs at the identical conditions.